• NOTE: DON'T load the software from the CD that came with the printer.  It has unnecessary software.
• Install the appropriate DYMO printer driver.  (32-bit)   (64-bit)  (ver 8.3.0.443) 
• Or latest from DYMO web site (latest = 8.5.0.542)
• Load labels into printer as instructed.  Note: labels load and print upside down. ( DYMO LabelWriter Manual)
• Plug printer into wall
• Plug USB cord into printer and into computer 
• Verify in "Devices and printers" that the DYMO printer shows up.   This can take several minutes.

• Start, Devices and Printers, r-click on Printing Preferences, Advanced:
• Set "Graphic: Print Quality" to 300 x 600 dots per inch
• Set "Printer Features: Print Quality" to  Barcodes and Graphics
• 
  
• Alternatively, you can get a faster print with poorer quality barcode with the following settings:
• Set "Graphic: Print Quality" to 300 x 300 dots per inch
• Set "Printer Features: Print Quality" to Text Only
• Set the printer print density to "light"